San Antonio, United States: innovation profile

San Antonio is number 114 in the 311 Innovation Cities Index, with an innovation score of 48. It is home to 8 R&D labs, 8 startups, 11 investors and 5 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Valero Energy (#53)
• iHeartMedia, Inc. (#1504)
• Rackspace Email (#1892)
• Clear Channel Outdoor (#2435)
• Cullen/Frost Bankers, Inc. (#F275)

Startups

• Darkhive
• Dura Software
• Insane Cyber
• Intelibly
• Nukudo Group
• RAI Partners
• RightSite Health
• Veritas Labs

Investors

• 1900 Wealth
• 327 Capital Partners
• Active Venture Partners
• Dry Line Partners
• Eldred Rock Partners
• Manifest Energy Transition
• Riverwalk Capital
• Riverwalk Capital
• Scaleworks Capital
• Swbc Investment
• Victory Capital

R&D labs

National Cancer Institute, South Texas Accelerated Research Therapeutics, Southwest Research Institute, Texas Biomedical Research Institute, Texas Center for Infectious Disease, Texas Diabetes Institute, United States Army Medical Research and Development Command, US Nuclear Regulatory Commission.