Ann Arbor, United States: innovation profile

Ann Arbor is number 204 in the 311 Innovation Cities Index, with an innovation score of 27. It is home to 9 R&D labs, 6 startups, 5 investors and 1 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Domino’s Pizza, Inc. (#1305)

Startups

• CatalogIt
• Evenergi Labs
• Heat2Power
• Sygaldry Technologies
• Visto 360 AI
• Volt Habor

Investors

• Arboretum Ventures
• RPM Ventures
• Speyside Equity
• Straylight Capital
• Topiary Capital

R&D labs

Environmental Research Institute of Michigan, National Sanitation Foundation International, NOAA Oceanic and Atmospheric Research, Therapeutics Systems Research Laboratories (United States), Toyota Motor North America (United States), United States Geological Survey, Universities in United States, University of Michigan, Warde Medical Laboratory.