Buffalo, United States: innovation profile

Buffalo is number 424 in the 311 Innovation Cities Index, with an innovation score of 11. It is home to 1 R&D lab, 4 startups, 1 investor and 2 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Gibraltar Industries (#2904)
• M&T Bank (#F132)

Startups

• Flox (US)
• Ognomy
• Positive Image Consulting Services
• Vicora

Investors

• Rand Capital

R&D labs

Roswell Park Comprehensive Cancer Center.