Chicago, United States: innovation profile

Chicago is number 5 in the 311 Innovation Cities Index, with an innovation score of 527. It is home to 5 R&D labs, 76 startups, 185 investors and 38 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Archer-Daniels-Midland Co. (#96)
• United Airlines Holdings, Inc. (#131)
• Mondelez International, Inc. (#208)
• McDonald's (#300)
• Exelon Corporation (#333)
• GE Healthcare Technologies Inc. (#396)
• Kellanova (#609)
• Motorola Solutions, Inc. (#660)
• Conagra Brands, Inc. (#676)
• Hyatt Hotels Corporation (#978)
• Cboe Global Markets, Inc. (#1328)
• Ryerson Holding Corporation (#1357)
• NIQ Global Intelligence plc (#1429)
• JBT Marel Corp. (#1526)
• Century Aluminum Co. (#1943)
• Morningstar, Inc. (#1980)
• Alight, Inc. (#2062)
• Coeur Mining (#2165)
• Covista (#2332)
• Gatx Corp. (#2347)
• Huron Consulting Group (#2405)
• Equity Lifestyle Properties Inc. (#2489)
• P3 Health Partners Inc. (#2565)
• Tempus AI, Inc. (#2765)
• Telephone & Data Systems Inc. (#2785)
• Green Thumb Industries Inc. (#2890)
• Rush Street Interactive, Inc. (#2906)
• CCC Intelligent Solutions Holdings Inc. (#3019)
• Jones Lang LaSalle Incorporated (#F61)
• CNA Financial Corporation (#F104)
• Old Republic International Corporation (#F144)
• Northern Trust Corporation (#F153)
• Cme Group Inc. (#F175)
• Ventas, Inc. (#F189)
• Kemper Corporation (#F207)
• TransUnion (#F216)
• Enova International, Inc. (#F259)
• Ryan Specialty Holdings, Inc. (#F261)

Startups

• Alluvial Finance
• AlphaBitCore
• Architect Financial Technologies
• Arvist
• Ascendco Health
• Auxira Health
• Bash Capital1
• Beacon Technology Solutions
• Brella Beverage
• CDM Field Services
• CIRC Biosciences
• Callpod
• Carallel
• Cargado
• Casters Holdings
• Catch Bio
• Classet
• Clearbox Decisions
• Coldcart
• Continuum Technologies
• Creator Networks
• Cube Group
• Dentologie Enterprises
• ER Logix
• Earthacre
• Electron Exchange Holdings
• Empirical Security
• FingerprintJS
• Funny Water
• G2
• GFX Labs
• Goose Holdings
• HumanImage
• IRD Holdings
• Imogene
• Instant Connect Holdings
• Justice Bid
• KeyCare
• Laconic Infrastructure Partners
• Lakril Technologies
• Leap Services
• Madison Scientific
• Mahalo Software
• Metopio
• Moonlite AI
• Moonnox
• Nutrad
• Ocient
• OrisDx
• Pathos AI
• Pimly
• Plutus Technology Solutions
• Praia Health
• QodeX Quantum
• Qumis
• Rent Butter
• Renterra
• Responsiv AI
• Resurgence Training Institute
• Revolution Global Health

And 16 more.

Investors

• 1ST & Main Growth Partners
• 50 South Capital
• 5TH Century Partners
• 7wire Management
• A1 Management
• Adams Street Partners
• Afo
• Agr Partners
• Air Asset
• Alerce Investment
• Altair Advisers
• Antares Capital
• Arch Venture Partners
• Arena Private Wealth
• Ariel Alternatives
• Ashland Forest Capital Partners
• Aurelien Capital
• Avathon Capital
• Balyasny Asset
• BCF Venture Partners
• BDT Capital Partners
• Benford Capital Partners
• Bluestein Ventures
• Bmo Family Office
• Bpoc
• Burford Capital Investment
• BW Capital Partners
• Center Rock Capital Partners
• Chicago Atlantic
• Chicago Pacific Founders
• Chicago Ventures
• Civc Partners
• Cleargate Capital Partners
• Cleveland Avenue
• CMT Asset
• Cold Bore Capital
• Constellation Wealth Capital
• Corazon Group
• Core Industrial Partners
• Creation Investments
• Cresset Asset
• Cressey
• Cultivian Sandbox
• Cultivian Sandbox Venture
• Curi Capital
• Debussy Capital
• Decasonic
• Delta Capital Partners
• Distributed Ventures
• Dixon Midland
• Driehaus Private Equity
• DRW Asset Management Us
• DV Capital
• E2p
• Edgewater Services
• Energize Capital
• Energy Capital Ventures
• Equator Capital Partners
• Equity International
• Erie Street Growth Partners

And 125 more.

R&D labs

Caterpillar, Chicago Center for Diabetes Translation Research, Institute for Food Safety and Health, Reproductive Genetics Institute, Tempus Labs (United States).