Cleveland, United States: innovation profile

Cleveland is number 91 in the 311 Innovation Cities Index, with an innovation score of 55. It is home to 4 R&D labs, 5 startups, 14 investors and 9 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• The Sherwin-Williams Company (#347)
• Parker-Hannifin Corporation (#409)
• Cleveland-Cliffs Inc. (#424)
• TransDigm Group Incorporated (#824)
• Applied Industrial Technologies, Inc. (#1358)
• Lincoln Electric (#1411)
• Hyster-Yale Materials Handling (#1530)
• Park Ohio Holdings Corp. (#2470)
• KeyCorp (#F159)

Startups

• Auxilium Health
• BPCP NSA Holdings
• BioMotiv
• Healthcare Navigation Solutions
• SuperCharger

Investors

• Blue Point Capital Partners
• Clearstead; Clearstead Advisory Solutions
• CW Industrial Partners
• Cyprium Partners
• GBX Fund Management
• Glasfunds
• Mai Capital
• Mcdonald Partners
• Mpe Partners
• Qovex
• Resilience Management
• Scaleco Capital
• Strategic Value Bank Partners
• The O.H.I.O. Fund

R&D labs

Cleveland Clinic, NASA, Orbital Research (United States), Orthopaedic Research Laboratories.