Houston, United States: innovation profile

Houston is number 9 in the 311 Innovation Cities Index, with an innovation score of 397. It is home to 11 R&D labs, 64 startups, 95 investors and 66 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Chevron Corporation (#30)
• Phillips 66 (#46)
• Sysco Corporation (#88)
• ConocoPhillips (#133)
• Enterprise Products Partners L.p. (#149)
• Plains All American Pipeline LP (#181)
• Plains GP Holdings LP (#182)
• SLB Limited (#224)
• NRG Energy, Inc (#260)
• LyondellBasell Industries N.V. (#262)
• Quanta Services, Inc. (#279)
• Baker Hughes Company (#293)
• Waste Management, Inc (#318)
• Eog Resources, Inc. (#364)
• Group 1 Automotive, Inc (#366)
• Halliburton (#370)
• Occidental Petroleum Corporation (#381)
• Cheniere Energy, Inc. (#408)
• Devon Energy Corp (#464)
• Targa Resources Corp. (#468)
• Kinder Morgan, Inc. (#472)
• Hess Corporation (#603)
• Westlake Corporation (#684)
• Cheniere Energy Partners, L.P. (#708)
• Sabine Pass Liquefaction, LLC (#719)
• Centerpoint Energy Inc (#783)
• Nov Inc. (#834)
• KBR, Inc. (#904)
• Coterra Energy Inc. (#920)
• Memorial Hermann Healthcare System (#921)
• Par Pacific Holdings, Inc. (#935)
• Cheniere Corpus Christi Holdings, LLC (#1051)
• Weatherford International plc (#1295)
• Chord Energy Corporation (#1309)
• Patterson-UTI Energy, Inc. (#1321)
• Service Corporation International (#1400)
• Crown Castle International Corp. (#1408)
• Crescent Energy Co. (#1581)
• Integrated Electrical Services (#1642)
• Kirby Corporation (#1643)
• Noble Corp plc (#1670)
• DNOW Inc. (#1827)
• Oceaneering International (#1855)
• Murphy Oil Corp. (#1875)
• Talen Energy Corp. (#1930)
• DXP Enterprises Inc. (#2178)
• Quanex Building Products Corp. (#2286)
• Comfort Systems USA (#2292)
• Talos Energy Inc. (#2337)
• Kinetik Holdings Inc. (#2340)
• Genesis Energy L.P. (#2424)
• Hess Midstream L.P. (#2427)
• TIC Solutions, Inc. (#2490)
• Bristow Group Inc. (#2543)
• Archrock, Inc. (#2544)
• Tidewater (#2673)
• National Energy Services Reunited Corp. (#2686)
• Magnolia Oil & Gas Corp. (#2692)
• Westlake Chemical Partners L.P. (#2893)
• Powell Industries (#2919)

And 6 more.

Startups

• AMPeers
• ATAP Market Technologies
• Ally Energy
• Arriba Foods
• AstroMind
• Atana Elements
• Autoimmunity Biologic Solutions
• Axiom Space
• Bectas Therapeutics
• Biostate AI
• Branch Therapeutics
• Cambrian Network
• Carbon Removal
• Cart.com
• CoRegen
• CrossBridge Bio
• Dev4
• Digital Wildcatters
• Euphree
• Frame Data AI
• Gold H2
• Goldenrod Therapeutics
• Hamilton Health Box
• Health for Everyone
• Helix Earth Technologies
• Hula Partners Holdings
• Ida Sports
• Invectys
• Kanin Energy
• LongFi Solutions
• Longevity Medical Institute
• Mallard Bay Outdoors
• March Biosciences
• Mechademy
• Molecule Software
• Mongoose Bio
• Motif Neurotech
• Octagos Health
• Oilfield Outpost II
• OncoMAGNETx
• Onvis
• PPC Diskover
• PieTech
• Prana Thoracic
• Procyrion
• RadioClash
• Recourse Biologics
• Regenimo Biosciences
• RepeatMD
• Rock Fiber
• Sage Geosystems
• SmartAC.com Holdings
• Smartchainservices Holdings
• Solution Energy
• Starling Medical
• SunGas Renewables
• Sydecar
• Synmax
• TYBR Health
• Utility Global

And 4 more.

Investors

• 922 Ventures
• Aec Holdings
• Allegro Mineral Partners
• Allied Industrial Partners
• Amberjack Capital Partners
• Americana Partners
• Amerisource Fund Management
• Andros Capital Partners
• Ara GC Partners
• Ara Partners
• Armadillo Litigation Funding
• Autumn Lane
• Avidian Wealth Solutions
• Bayou City Energy
• Blackgold Capital
• Broadvail Capital Partners
• Buckhorn Resources
• Bull & Bear
• Carnelian Energy Capital
• Caz Investments
• Chambers Energy Capital
• Climate Investment
• Clovis Point Capital
• Covalence Investment Partners
• CRG
• Crosstimbers Capital Group
• CSL Capital
• Dauntless Capital Partners
• Doliver Advisors
• Eiv Capital
• Elda River Capital
• Encap Etf
• Encap Investments
• Eoc Partners
• Fannin Advisory
• Fic Partners
• Five Point Infrastructure
• Flagship Investment
• Gec Advisors
• Geneses Investment
• Granite Harbor
• Haddington Ventures
• Hines Capital
• Intrepid Investment
• Junction Energy Capital
• Juniper Capital
• Kayne Anderson Capital
• Latitude 37 Ventures
• LDR Partners
• Leggett Ventures
• Lilium Group
• Live Oak Resource Partners
• Loftyinc Capital
• Mercury Fund
• Milton Street Capital
• Montrose Lane
• Mountain Capital
• Nexten Management
• North Hudson Resource Partners
• Novellus Ventures LS1

And 35 more.

R&D labs

Agricultural Research Service - Plains Area, Alkek Center for Molecular Discovery, Baylor College of Medicine, Chevron, Core Laboratories (United States), Houston Forensic Science Center, Houston Institute for Clinical Research, NASA, Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas Health Science Center at Houston, TomoWave Laboratories (United States).