Indianapolis, United States: innovation profile

Indianapolis is number 94 in the 311 Innovation Cities Index, with an innovation score of 53. It is home to 5 R&D labs, 24 startups, 5 investors and 7 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Elevance Health, Inc. (#27)
• Eli Lilly and Company (#113)
• Corteva, Inc. (#456)
• Elanco Animal Health Inc (#1336)
• Calumet, Inc. (#1436)
• Allison Transmission Holdings Inc. (#1756)
• Simon Property Group, Inc. (#F178)

Startups

• 3Aware
• Backstroke
• Bearing Security
• CTOS Software
• Casted
• ChampionHQ
• Croft Technology
• Flaunt Software
• GeniPhys
• GeoH
• Habits
• Kennected
• Liminal AI
• Lite Magnesium Products
• Oaken
• Overfuel
• PinkDx
• Quantum Corridor
• RootNote
• South Campus Surgery Center
• Stamus Networks
• Stellar Technology Services
• Trava Security
• Wavelength Labs

Investors

• Alloy Partners
• Centerfield Capital Partners
• Fi3 Financial
• Ground Game Ventures
• High Alpha Studio

R&D labs

American College of Sports Medicine, Eli Lilly, Hoosier Cancer Research Network (United States), Indiana Clinical and Translational Sciences Institute, Indiana Criminal Justice Institute.