Louisville, United States: innovation profile

Louisville is number 153 in the 311 Innovation Cities Index, with an innovation score of 37. It is home to 2 R&D labs, 11 startups, 5 investors and 7 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Humana Inc. (#47)
• BrightSpring Health Services, Inc. (#602)
• Yum! Brands, Inc. (#877)
• Texas Roadhouse, Inc. (#1138)
• Brown-Forman (#1273)
• Churchill Downs Inc. (#1790)
• Papa John's (#2171)

Startups

• ADEM Technologies
• Bert Thin Films
• H3X Technologies
• Igniton
• Iribamaps
• LYLA Concierge
• Raapid
• SoFab Inks
• Visor Health
• Zephr.xyz
• eBlu Solutions

Investors

• Castellan
• Chrysalis Ventures
• Oak Proof
• PNC Real Estate
• Unifi Ventures

R&D labs

Jewish Hospital, Louisville Metabolic and Atherosclerosis Research Center.