Madison, United States: innovation profile

Madison is number 122 in the 311 Innovation Cities Index, with an innovation score of 45. It is home to 8 R&D labs, 13 startups, 9 investors and 3 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Alliant Energy (#1393)
• Anywhere Real Estate Inc. (#F192)
• Deere John Capital Corp (#F204)

Startups

• AIQ Global
• Anada
• Cardamom Health
• Earth RepAIR Global
• Elephas Biosciences
• On3
• Optical X
• Protegera
• Pyran
• Realta Fusion
• Slot Check
• Synthec Fuels Wisconsin
• aMBR Genomics

Investors

• Acadian Ventures
• American Family Ventures
• Gener8tor
• Healthx Management
• Nvng Investment
• Rock River Capital Partners
• Transcend Capital
• Trustage Investment
• Venture Investors

R&D labs

Agricultural Research Service - Midwest Area, Bellbrook Labs (United States), Institute for Research on Poverty, International Breast Cancer Research Foundation, United States Department of Energy, University of Wisconsin–Madison, US Forest Service, WiCell.