Pittsburgh, United States: innovation profile

Pittsburgh is number 54 in the 311 Innovation Cities Index, with an innovation score of 77. It is home to 10 R&D labs, 17 startups, 10 investors and 15 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• Kraft Heinz (#327)
• WESCO International, Inc. (#348)
• PPG Industries, Inc. (#497)
• United States Steel Corp (#505)
• Alcoa Corp (#607)
• Westinghouse Air Brake Technologies Corporation (#685)
• Howmet Aerospace Inc. (#869)
• American Eagle Outfitters, Inc. (#1180)
• Kennametal (#2221)
• Koppers Holdings Inc. (#2269)
• Federated Hermes (#2301)
• Matthews International Corp. (#2542)
• Duolingo, Inc. (#3028)
• PNC Financial Services Group, Inc (#F75)
• FNB Corp. (#F273)

Startups

• 1486 Labs
• Aethl Bio
• Diamond Kinetics
• Duo Oncology
• EfficientAI
• Garden Club Penn
• Gray Swan Security
• Lovelace AI
• Mine Vision Holdings
• NovoLINC
• PointsVille
• Respair
• Rimsys
• Shelfmark
• Vigilant Ops
• Wood Wide AI
• Xlue

Investors

• Agility Equity Partners
• Allegheny Financial Group
• Birchmere Management
• Btnv Management
• Continuim Equity Partners
• Draper Triangle
• Hunter Private Capital
• Incline Equity Partners
• Partners Edge
• Quattro Advisors

R&D labs

Bosch, Carnegie Mellon University, Magee-Womens Research Institute, Pittsburgh Supercomputing Center, Uber, Universities in United States, University of Pittsburgh, University of Pittsburgh, US Department of Defense, US Department of Energy.