Sioux Falls, United States: innovation profile

Sioux Falls is number 475 in the 311 Innovation Cities Index, with an innovation score of 10. It is home to 2 R&D labs, 2 startups, 2 investors and 1 of the world's largest companies in the 311 Institute directories.

Part of the 311 Innovation Cities Index (311institute.com). Last updated 7 October 2026.

Largest companies

• NorthWestern Energy Group, Inc. (#2434)

Startups

• Balance Ophthalmics
• Prismatic Software

Investors

• Bird Dog Equity Partners
• Bluestem Capital

R&D labs

Sanford Health, US Geological Survey.