AI predicts human disease risk up to 20 years before symptoms emerge
Seeing the future is the ultimate skill ... and being able to predict disease symptoms 20 years before people fall ill is impressive.
Key takeaways
- The researchers collaborated from the German Cancer Research Center, the University of Copenhagen, and the European Molecular Biology Laboratory.
- The researchers said their AI tool can predict diseases up to 20 years in advance, especially cancers, heart attacks, and other conditions with predictable disease progression.
- Regarding Delphi-2M, the researchers plan to conduct additional tests of its AI tool on different population groups and in various countries.
Cite or link to this article
Griffin, M. (2025) 'AI predicts human disease risk up to 20 years before symptoms emerge', 311 Institute, 7 November. Available at: https://www.311institute.com/ai-predicts-human-disease-risk-up-to-20-years-before-symptoms-emerge/ (Accessed: 1 October 2026).
We’ve seen Artificial Intelligence (AI) models that can predict human disease, and even a rough time of death, before but now a new system can predict human disease risks up to 10 to 20 years before symptoms even occur. As Innovation Origins reported, researchers developed Delphi-2M using over 40,000 Biobank participants and 1.9 million Danish medical records. It can accurately predict the progression of diseases, including type 2 diabetes and heart attacks.
The researchers collaborated from the German Cancer Research Center, the University of Copenhagen, and the European Molecular Biology Laboratory. They published their scientific findings in the journal Nature.
The AI tool identifies high-risk individuals and enables doctors to implement early intervention measures.
The Future of Healthcare 2030, by Futurist Matthew Griffin
It does this by analyzing patients' medical history and relevant factors, such as obesity and age. It's a unique tool because it can predict over 1,000 diseases simultaneously with impressive accuracy. Previous models reportedly could only predict single, targeted diseases.
The researchers said their AI tool can predict diseases up to 20 years in advance, especially cancers, heart attacks, and other conditions with predictable disease progression.
This amazing technological development offers hope for improving people's health and empowering individuals to make positive lifestyle changes to halt the progression of disease.
There's no denying that AI has concerning environmental impacts due to its extreme energy usage and strain on electrical grids. However, the technology also holds great promise for predicting everything from diseases to dangerous storms to the clean energy transition.
As AI technology continues to advance, it has the potential to address many of the critical climate issues our world faces.
Regarding Delphi-2M, the researchers plan to conduct additional tests of its AI tool on different population groups and in various countries. They recognize the need to refine further and test the tool before it's ready for clinical use, hopefully within a few years.
In their publication, the researchers wrote, "In summary, transformer-based models appear to be well suited for predictive and generative health-related tasks, are applicable to population-scale datasets and provide insights into temporal dependencies between disease events, potentially improving the understanding of personalized health risks and informing precision medicine approaches."
"If our model says it's a one-in-10 risk for the next year, it really does seem like it turns out to be one in 10," Professor Ewan Birney from the European Molecular Biology Laboratory commented on the AI tool's reliability, per Innovation Origins.
FAQ
Why does this matter?
Seeing the future is the ultimate skill ... and being able to predict disease symptoms 20 years before people fall ill is impressive.

About the author
Matthew Griffin Founder, 311 Institute
Matthew Griffin is a multi-award winning Futurist and expert in Disruption and Innovation, Geopolitics, Leadership, and Technology, who NASA have described as a "walking encyclopaedia of the future" and a "futurist Polymath."
Read full bio
Matthew Griffin is a multi-award winning Futurist and expert in Disruption and Innovation, Geopolitics, Leadership, and Technology, who NASA have described as a "walking encyclopaedia of the future" and a "futurist Polymath." 15-time best selling author of the "Codex of the Future" series, Matthew is the Founder and Futurist in Chief of the 311 Institute, a global Futures and Deep Futures advisory firm working with royal households, world leaders, G7, G20, and G77 governments, NGOs, and multi-national mid and mega cap firms to help them explore, shape, and lead the next 50 years of business and society.
An award-winning YouTube creator with over a million followers, with an unrivalled global reach and impact, Matthew is a highly sought-after international keynote speaker, lecturer, and mentor who collaborates with global leaders through the United Nations Alliance of Civilizations (UNAOC) and United Nations General Assembly (UNGA) to shape pivotal initiatives such as the UN’s AI for Humanity program, the United Nations Conference of the Parties (UN COP), and the World Economic Forum in Davos.
As the former Global Head of Cloud, National Security, and Enterprise Sales for companies including Atos, Dell-EMC, and IBM, Matthew has a proven track record of building multi-billion dollar business units and turning failing divisions into market leaders. His ability to identify, analyse, and communicate the implications of hundreds of emerging technologies and trends is unparalleled, and his insights are trusted by many of the world’s most respected organisations, including ABB, Accenture, Adidas, AON, ARM, BCG, Centrica, Citi, Coca-Cola, Dentons, Deloitte, Dow Jones, EY, Google, KPMG, Lego, Legal & General, LinkedIn, Microsoft, PepsiCo, Qualcomm, RWE, Samsung, Siemens AG and Siemens Energy, T-Mobile, UBS, VISA, Walmart, Workday, Worldpay and many others.
Regularly featured in the global media including the AP, BBC, Bloomberg, CNBC, Discovery, Forbes, Khaleej Times, Telegraph, TIME, ViacomCBS, WIRED, and the WSJ, Matthews mission is to help organisations create a fair and sustainable future whose benefits are shared by everyone irrespective of their ability, background, or circumstances.
What future do you need to see?
Choose one to get started on AI and intelligence and the future of your organisation.
Sources and further reading
- New ai spots disease risks years before symptoms show ioplus.nl
- S41586 025 09529 3 nature.com
Source: first published by the 311 Institute on 7 November 2025. Cite as: Griffin, M. (2025). AI predicts human disease risk up to 20 years before symptoms emerge. 311 Institute. https://www.311institute.com/ai-predicts-human-disease-risk-up-to-20-years-before-symptoms-emerge/
You are welcome to quote this article with credit and a link to the original.